{"id":61365,"date":"2023-04-06T04:00:23","date_gmt":"2023-04-06T08:00:23","guid":{"rendered":"https:\/\/cablemanpro.com\/wallstreetpr\/covid-vaccine-nasal-spray-shows-strong-immune-response-in-study-could-be-a-game-changer-61365"},"modified":"2023-04-06T04:00:23","modified_gmt":"2023-04-06T08:00:23","slug":"covid-vaccine-nasal-spray-shows-strong-immune-response-in-study-could-be-a-game-changer","status":"publish","type":"post","link":"https:\/\/cablemanpro.com\/wallstreetpr\/covid-vaccine-nasal-spray-shows-strong-immune-response-in-study-could-be-a-game-changer-61365","title":{"rendered":"COVID vaccine nasal spray shows strong immune response in study: ‘Could be a game changer’"},"content":{"rendered":"
\n

A new study has shown promising results for a nasal COVID-19 vaccine<\/u><\/a>, according to researchers at the Institute of Virology at Freie Universit\u00e4t Berlin in Germany.\u00a0<\/p>\n

When two doses of the live nasal vaccine were administered to hamsters, the animals showed a stronger immune response compared to their response to two doses of the vaccines that are currently available.<\/p>\n

The study was published in the journal Nature Microbiology on Monday.<\/p>\n

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The lead author of the study told Fox News Digital this week, “We find that a live attenuated vaccine prevents virus replication \u2014 this could be a game changer in controlling SARS-CoV-2 transmission.”<\/p>\n

Today, there are four approved COVID vaccines<\/u><\/a> in the U.S. \u2014 all of which are administered via injection into the muscle, per the Centers for Disease Control and Prevention (CDC).<\/p>\n

The Pfizer-BioNTech and Moderna vaccines are both mRNA vaccines, which use mRNA (messenger RNA) to trigger cells to produce a viral protein.\u00a0<\/p>\n

This prompts the immune system to create antibodies.<\/p>\n

Johnson & Johnson\u2019s Janssen is a viral vector vaccine, which delivers DNA “instructions” to the body\u2019s cells via a different, non-harmful virus.<\/p>\n

The Novavax vaccine is a protein subunit vaccine, which uses some proteins of the virus that causes COVID-19 \u2014 known as the “spike protein” \u2014 to “train” the immune system to act against future spike proteins.<\/p>\n

The nasal COVID vaccine that’s being tested is a live-attenuated vaccine, which means it contains a live but weaker form of the coronavirus.\u00a0<\/p>\n

It works by stopping the virus in the upper airway before it can travel further into the body.<\/p>\n

The researchers used Syrian hamsters for their vaccine testing.\u00a0<\/p>\n

The study\u2019s lead author, Dr. Jakob Trimpert, head of diagnostics at the Institute of Virology at Freie Universit\u00e4t Berlin in Germany<\/u><\/a>, said hamsters are the “prime non-transgenic [not genetically modified] small animal model” for COVID-19 research.<\/p>\n

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“These animals have the great advantage of being naturally susceptible to SARS-CoV-2 infection, including natural spread between hamsters,” he explained to Fox News Digital.\u00a0<\/p>\n

“The infection of Syrian hamsters resembles many key features of moderate human COVID-19 \u2014 this makes the hamster an ideal model to study COVID-19 vaccines and therapies<\/u><\/a>.”<\/p>\n

The nasal vaccines have significant advantages over the injectable vaccines that are currently available, Dr. Trimpert said.\u00a0<\/p>\n

“An intra-nasally applied live-attenuated vaccine provides superior protection against SARS-CoV-2 infection<\/a> compared to intramuscularly applied vaccines,” he told Fox News Digital.<\/p>\n

While he said currently marketed vaccines do a good job of preventing severe illness from COVID, Dr. Trimpert pointed out that they don’t prevent the infection, moderate illness or spread.<\/p>\n

“We find that a live attenuated vaccine prevents virus replication” \u2014 so “this could be a game changer in controlling SARS-CoV-2 transmission.”<\/p>\n

The main benefit of a nasal vaccine is that immunity is activated right where it\u2019s needed, Dr. Trimpert said.<\/p>\n

“It is the induction of local immunity at the site of natural infection that could be a game-changer here,” he said.\u00a0<\/p>\n

“Judging from our results, this has considerable impact and greatly reduces the risk of infection.”<\/p>\n

Dr. Marc Siegel, professor of medicine at NYU Langone Medical Center<\/u><\/a> and a Fox News medical contributor, said he finds this new research promising. He was not involved in the study.<\/p>\n

“The goal is very important: to create a barrier to stop virus spread,” he told Fox News Digital.<\/p>\n

“This involves IGA antibodies and works at the level of the mucus membranes.”\u00a0<\/p>\n

IGA, or Immunoglobulin A, is an antibody that plays an important part in the immune function of mucous membranes.<\/p>\n

The mucous membrane, or the nasal mucosa, is the tissue that lines the nasal cavity.<\/p>\n

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The nasal vaccine could be standalone or could work in conjunction with other vaccines, said Dr. Siegel.\u00a0<\/p>\n

“If it\u2019s effective and human trials of the German vaccine are ongoing, it will be a big step forward,” he said.<\/p>\n

Dr. Norman B. Gaylis, who has treated over 1,000 patients at his Long Haul COVID Clinic in Aventura, Florida<\/u><\/a>, also reviewed the findings.<\/p>\n

“I believe it\u2019s a brilliant idea to create a vaccine that can build immunity in the nasal mucosa,” he told Fox News Digital.\u00a0<\/p>\n

“Research has shown that COVID and other viruses often enter through the nose, and travel up the olfactory nerve \u2026 and then into the brain,” he explained.<\/p>\n

Developing a nasal vaccine could help prevent viruses from gaining easy access to the brain, said Dr. Gaylis.\u00a0<\/p>\n

“This is important because many \u2018long COVID\u2019 patients are reporting brain damage from the virus,” he added.<\/p>\n

MOST ‘LONG COVID’ SYMPTOMS AFTER MILD CASE OF VIRUS RESOLVE IN ABOUT A YEAR: NEW STUDY<\/u><\/strong><\/a><\/p>\n

Additionally, a nasal vaccine would provide a helpful alternative for patients who have a fear of needles, allowing them to get protected without a jab, said the doctor.<\/p>\n

As of July 2022, there were at least 12 nasal COVID vaccines in clinical development, according to Science Immunology.<\/p>\n

The biotechnology company Codagenix announced in October 2022 that it had entered the Phase 3 clinical trial for CoviLiv, its intranasal COVID-19 vaccine that is intended for healthy adults<\/u><\/a>.<\/p>\n

The Icahn School of Medicine at Mount Sinai in New York City has launched a Phase 1 study evaluating a new egg-based COVID vaccine, called NDV-HXP-S, which can be administered nasally or via muscular injection.<\/p>\n

In June 2022, the National Institute of Allergy and Infectious Diseases published a study illustrating the effectiveness of nasal COVID vaccines in hamsters.\u00a0<\/p>\n

This was followed by another study in September 2022, which showed that nasal vaccines produced a strong immune response in rhesus monkeys.<\/p>\n

CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER<\/u><\/strong><\/a><\/p>\n

Both China and India have approved nasal COVID vaccines for humans, as reported in the journal Nature in September 2022.<\/p>\n

Iran and Russia have also approved nasal forms of the vaccine, though there is limited data available about their effectiveness.<\/p>\n

The German research team plans to continue investigating the effectiveness of its vaccines and looks forward to moving into clinical trials.<\/p>\n

“While our results in the animal model are robust, only clinical trials will be able to ascertain translatability to human medicine,” Dr. Trimpert said.<\/p>\n

Questions remain about the vaccine\u2019s safety for people with weakened immune systems and the potential risk of combining it with different variants of the virus.<\/p>\n

The CDC states that severely immunocompromised people and pregnant women<\/u><\/a> should avoid live vaccines.<\/p>\n

Said Dr. Trimpert, “We do think there is reason to hope for next-generation COVID-19 vaccines that better control virus transmission and greatly reduce disease burden.”<\/p>\n<\/div>\n

Source – https:\/\/www.foxnews.com\/health\/covid-vaccine-nasal-spray-shows-strong-immune-response-study-could-be-game-changer <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

A new study has shown promising results for a nasal COVID-19 vaccine, according to researchers at the Institute of Virology at Freie Universit\u00e4t Berlin in […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"rop_custom_images_group":[],"rop_custom_messages_group":[],"rop_publish_now":"initial","rop_publish_now_accounts":{"twitter_2902945987_2902945987":""},"rop_publish_now_history":[],"rop_publish_now_status":"pending","footnotes":""},"categories":[16563],"tags":[],"stock_ticker":[],"class_list":["post-61365","post","type-post","status-publish","format-standard","hentry","category-market-news","entry"],"acf":[],"yoast_head":"\nCOVID vaccine nasal spray shows strong immune response in study: 'Could be a game changer' - Wall Street PR<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cablemanpro.com\/wallstreetpr\/covid-vaccine-nasal-spray-shows-strong-immune-response-in-study-could-be-a-game-changer-61365\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"COVID vaccine nasal spray shows strong immune response in study: 'Could be a game changer' - 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