{"id":142616,"date":"2026-08-12T15:23:22","date_gmt":"2026-08-12T19:23:22","guid":{"rendered":"https:\/\/cablemanpro.com\/wallstreetpr\/cancer-warning-signs-may-appear-in-dna-years-before-blood-tests-detect-trouble-142616"},"modified":"2026-08-12T15:23:22","modified_gmt":"2026-08-12T19:23:22","slug":"cancer-warning-signs-may-appear-in-dna-years-before-blood-tests-detect-trouble","status":"publish","type":"post","link":"https:\/\/cablemanpro.com\/wallstreetpr\/cancer-warning-signs-may-appear-in-dna-years-before-blood-tests-detect-trouble-142616","title":{"rendered":"Cancer warning signs may appear in DNA years before blood tests detect trouble"},"content":{"rendered":"
\n

DNA patterns could reveal whether certain blood cancers<\/a> are progressing years before routine tests detect those changes, new research suggests.<\/p>\n

The study, published in the journal Cancer Discovery by the American Association for Cancer Research<\/a>, followed 30 people with myeloproliferative neoplasms (MPNs), a group of blood cancers in which the bone marrow produces too many blood cells.<\/p>\n

Researchers monitored DNA in the patients\u2019 blood and bone marrow for genetic changes<\/a>, then examined whether those changes were associated with blood counts, stable disease or progression to myelofibrosis or acute leukemia.<\/p>\n

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People who stayed stable often had stable DNA, without cancer-related genetic changes. This suggests a genetically “quiet” MPN is more likely to remain stable, according to the researchers, who are based at the Wellcome Trust Sanger Institute in the U.K.<\/p>\n

Patients whose disease worsened often showed DNA changes years before routine blood tests detected progression, as new groups of abno<\/span>rmal cells emerged and grew, according to the study.<\/p>\n

Nine participants eventually developed acute myeloid leukemia<\/a> (AML), but their disease did not progress in the same way.<\/p>\n

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In some, MPN cells gradually accumulated harmful mutations; in others, the leukemia appeared to arise from a separate group of abnormal blood cells. Similar differences were seen in those who developed myelofibrosis.<\/p>\n

The researchers also found that hydroxyurea \u2014 a common medication used to control blood counts in people with MPN \u2014 leaves a recognizable pattern of small DNA changes in blood cells. There was no evidence, however, that the drug causes leukemia. A similar pattern was linked to azacitidine, a drug used to treat certain blood cancers.<\/p>\n

Three participants had “triple-negative” essential thrombocythemia, a condition generally classified as a blood cancer, yet researchers found no genetic signs of cancer in their samples.<\/p>\n

The finding raises the possibility that some patients given this diagnosis may not have a malignant disease and may not need long-term cancer treatment<\/a>.<\/p>\n

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The study was limited by its small sample size, and the findings show associations rather than establishing cause and effect.<\/p>\n

In an interview with Fox News Digital, Abhishek Chilkulwar, M.D., an oncologist with Orlando Health, noted that most people with MPNs can live with them “for decades.”<\/p>\n

The doctor, who was not involved in the study, called the findings a “striking demonstration” that DNA changes may signal the development of certain cancers<\/a> a decade before diagnosis \u2014 and that their future path may “already be ‘written’ in a patient’s cells long before doctors can see any outward sign.”<\/p>\n

“More broadly, it’s an early example of what could become precision medicine for blood cancer prevention \u2014 using a patient’s own genetic data to predict risk years in advance, then someday intervening before disease progression rather than only treating it after the fact,” he said.<\/p>\n

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“That’s the direction this kind of research is pointing, even though the tools to act on it aren’t fully built yet.”<\/p>\n

The results suggest that periodically re-testing a patient\u2019s DNA over time could give doctors a “heads up” that someone\u2019s disease is heading in a dangerous direction, “well before” it shows up in routine blood work, Chilkulwar added.<\/p>\n

“In the near term, the realistic use of this is modest: closer monitoring, not new treatment,” he said. “A patient found to have acquired a high-risk mutation could be shifted to more frequent blood counts and, if warranted, more frequent bone marrow checks \u2014 so if progression does happen, it’s caught earlier<\/a>.”<\/p>\n

“It would not be a reason to start stem cell transplant<\/a> evaluation; transplant is a serious procedure appropriately reserved for patients who have actually progressed to myelofibrosis or AML, not something to prepare for based on a mutation that might cause problems years down the line,” the doctor cautioned.<\/p>\n

The next step, Chilkulwar said, would be pairing early genetic detection with drugs targeting those specific mutations, potentially preventing or delaying disease progression.<\/p>\n<\/div>\n

Source – https:\/\/www.foxnews.com\/health\/cancer-warning-signs-may-appear-dna-years-before-blood-tests-detect-trouble <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

DNA patterns could reveal whether certain blood cancers are progressing years before routine tests detect those changes, new research suggests. 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