{"id":135052,"date":"2026-06-09T13:19:00","date_gmt":"2026-06-09T17:19:00","guid":{"rendered":"https:\/\/cablemanpro.com\/wallstreetpr\/diabetes-drug-could-slash-risk-of-fatal-heart-condition-in-one-group-scientists-reveal-135052"},"modified":"2026-06-09T13:19:00","modified_gmt":"2026-06-09T17:19:00","slug":"diabetes-drug-could-slash-risk-of-fatal-heart-condition-in-one-group-scientists-reveal","status":"publish","type":"post","link":"https:\/\/cablemanpro.com\/wallstreetpr\/diabetes-drug-could-slash-risk-of-fatal-heart-condition-in-one-group-scientists-reveal-135052","title":{"rendered":"Diabetes drug could slash risk of fatal heart condition in one group, scientists reveal"},"content":{"rendered":"
\n

A diabetes<\/a> drug could help lower the risk of heart failure in certain patients.<\/p>\n

A new study published in Nature Medicine analyzed how SGLT2 inhibitor dapagliflozin, a medication used to treat type 2 diabetes, could help prevent heart failure in people with rare genetic variants linked to cardiomyopathy (a progressive disease of the heart muscle).<\/p>\n

Using data from the DECLARE-TIMI 58 trial, researchers from Harvard Medical School, Mass General Brigham and MIT looked at more than 12,000 adults who had type 2 diabetes and increased cardiovascular risk<\/a>.<\/p>\n

VITAMIN SUPPLEMENT MAY DELAY DIABETES IN SELECT GROUPS, RESEARCHERS SAY<\/strong><\/a><\/p>\n

About 121 participants carried inherited gene variants that could raise their chances of developing cardiomyopathy.<\/p>\n

After a median 4.2-year follow-up, dapagliflozin was found to lower hospitalization for heart failure more in individuals with the variants than in those without.<\/p>\n

While dapagliflozin lowered heart failure hospitalization<\/a> in both groups, the reduction was about eight times stronger in carriers of the genetic variant.<\/p>\n

Among the 82% of carriers without a prior history of heart failure, 12.8% developed heart failure in the placebo group, while no heart-failure events were observed among carriers receiving dapagliflozin.<\/p>\n

DIABETES STUDY REVEALS DIAGNOSIS GAP AFFECTING MILLIONS OF PEOPLE<\/strong><\/a><\/p>\n

Co-lead study author Shinwan Kany, MD, a visiting scientist at the Cardiovascular Research Center with Mass General Brigham Heart and Vascular Institute and the Broad Institute, commented on how these findings could shape preventive care<\/a>.<\/p>\n

“Historically, identifying a genetic variant for cardiomyopathy mostly meant telling a patient they were at high risk and not having a specific preventive therapy to offer,” he said in a press release. “These data show we do have tools to lower risk in these individuals.”<\/p>\n

As this was an analysis of a larger randomized trial, the results require further confirmation, according to experts. The narrow sample size of carriers also poses a limitation.<\/p>\n

DIABETES, HEART DISEASE CASES SKYROCKET \u2014 AND SCIENTISTS PINPOINT ONE KEY REASON<\/strong><\/a><\/p>\n

“These findings are very encouraging because they suggest we may be entering an era where heart failure prevention becomes more precise and more genetically informed<\/a>,” Andrew Freeman, MD, a cardiologist at National Jewish Health, told Fox News Digital.<\/p>\n

Freeman, who was not involved in the study, called the research “important and provocative.”<\/p>\n

Participants with no history of heart failure who took dapagliflozin were less likely to develop the condition, a finding that “raises the possibility that SGLT2 inhibitors may be especially useful as preventive therapy in genetically high-risk individuals,” the doctor said.<\/p>\n

“This should be viewed as an exciting hypothesis-generating finding, not yet a practice-changing mandate for all patients with these genetic variants,” Freeman cautioned.<\/p>\n

SGLT2 inhibitors are already “foundational” cardiovascular and kidney-protective medications<\/a>, the doctor noted.<\/p>\n

CLICK HERE FOR MORE HEALTH STORIES<\/strong><\/a><\/p>\n

“They reduce heart failure hospitalization across a broad range of patients, including those with diabetes, chronic kidney disease and established heart failure,” he said. “What this study adds is the possibility that genetic information may help identify a subgroup of people who derive especially large benefit from early treatment.”<\/p>\n

CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER<\/strong><\/a><\/p>\n

Genetic testing<\/a> for cardiomyopathy is often used for diagnosis, family screening and risk stratification, Freeman said.<\/p>\n

If future clinical trials confirm the findings, cardiologists could eventually use genetic screening to identify high-risk patients, monitor them more closely, and begin treatments such as SGLT2 inhibitors before heart failure<\/a> symptoms appear, according to the cardiologist.<\/p>\n

Heart failure does not always begin when symptoms appear, Freeman noted. In some patients, risk may be present years earlier due to inherited genetics.<\/p>\n

TEST YOURSELF WITH OUR LATEST LIFESTYLE QUIZ<\/strong><\/a><\/p>\n

Preventive cardiology could identify high-risk patients<\/a> earlier, before they develop symptoms such as shortness of breath, fluid retention or the need for hospitalization.<\/p>\n

The decision to medicate should always be discussed with a clinician, Freeman advised, especially for those with a personal or family history of cardiovascular events.<\/p>\n<\/div>\n

Source – https:\/\/www.foxnews.com\/health\/diabetes-drug-could-slash-risk-fatal-heart-condition-one-group-scientists-reveal <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

A diabetes drug could help lower the risk of heart failure in certain patients. 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