{"id":125259,"date":"2026-03-24T07:00:21","date_gmt":"2026-03-24T11:00:21","guid":{"rendered":"https:\/\/cablemanpro.com\/wallstreetpr\/stopping-glp-1-drugs-like-ozempic-erodes-heart-health-benefits-quickly-new-study-finds-125259"},"modified":"2026-03-24T07:00:21","modified_gmt":"2026-03-24T11:00:21","slug":"stopping-glp-1-drugs-like-ozempic-erodes-heart-health-benefits-quickly-new-study-finds","status":"publish","type":"post","link":"https:\/\/cablemanpro.com\/wallstreetpr\/stopping-glp-1-drugs-like-ozempic-erodes-heart-health-benefits-quickly-new-study-finds-125259","title":{"rendered":"Stopping GLP-1 drugs like Ozempic erodes heart health benefits quickly, new study finds"},"content":{"rendered":"
\n

People who stop taking popular weight-loss and diabetes medications may lose out on any heart health benefits<\/a> the medications provided.<\/p>\n

GLP-1 receptor agonists \u2014 such as semaglutide (Ozempic and Wegovy), and tirzepatide (Mounjaro and Zepbound) \u2014 have been shown to reduce the risk of heart attack and stroke<\/a>.<\/p>\n

A new study from the Washington University School of Medicine in St. Louis explored the effects of quitting \u2014 particularly related to cardiovascular health.<\/p>\n

NEW OZEMPIC-ALTERNATIVE DIABETES PILL BURNS FAT WITHOUT MUSCLE LOSS, STUDY SUGGESTS<\/strong><\/a><\/p>\n

“Many people are excited to start GLP-1s, but many stop within a few months,”\u00a0Ziad Al-Aly, senior clinical epidemiologist at WashU Medicine, told Fox News Digital.<\/p>\n

“Some research looked at weight regain<\/a> after people stop \u2014 we wanted to know what happens to heart health when people stop.”<\/p>\n

While GLP-1 drugs lead to weight loss, they also reduce cholesterol, blood pressure<\/a>, inflammation and insulin resistance, the researcher noted. “When people stop, these start going in the wrong direction.”<\/p>\n

In the observational study, researchers followed more than 333,000 U.S. veterans with type 2 diabetes for about three years, comparing those taking GLP-1s to those taking sulfonylureas (oral medications<\/a> used to treat type 2 diabetes).<\/p>\n

They found that those who used GLP-1s continuously for three years had an 18% reduction in cardiovascular risk, according to the study, which was published in BMJ Medicine.<\/p>\n

“We found that stopping erodes the heart protection<\/a> these drugs provide,” Al-Aly said. “It took three years of continuous use to achieve an 18% reduction in heart attack, stroke and death \u2014 but that protection erodes fast.”<\/p>\n

WHAT ARE GLP-3S? MEET THE NEW GENERATION OF WEIGHT-LOSS DRUGS WITH THREE KEY INGREDIENTS<\/strong><\/a><\/p>\n

Stopping for six months raised the risk by 4%, one year elevated it by 14%, and two years off the medication raised the risk by 22%.<\/p>\n

The researchers were most surprised by how quickly the benefits were lost. “We expected some loss of benefit after stopping, but the pace was striking,” Al-Aly said. “Protection that takes years to accumulate can vanish in a few months of stopping.”<\/p>\n

When the patients started taking GLP-1s again after quitting, they experienced a partial but not full heart health benefit (a 12% reduced risk compared to 18% if they hadn\u2019t stopped).<\/p>\n

“Restarting helped, but it didn’t fully restore the protection of uninterrupted use,” the researcher emphasized. “Discontinuation leaves a lasting scar. That tells us the damage from stopping isn’t fully reversible, and that has real implications for the millions of people cycling on and off these drugs.”<\/p>\n

OLDER AMERICANS ARE QUITTING GLP-1 WEIGHT-LOSS DRUGS FOR 4 KEY REASONS<\/strong><\/a><\/p>\n

Dr. Bradley Serwer, an interventional cardiologist and chief medical officer at VitalSolution, an Ingenovis Health company that offers cardiovascular and anesthesiology services to hospitals, agreed that the findings were not unexpected.<\/p>\n

“When treating patients with chronic diseases, the primary objective is long-term success,” the Maryland-based doctor, who was not involved in the study, told Fox News Digital. “This is achieved through behavioral modification, lifestyle changes<\/a>, improved heart-healthy diets and medical therapy.”<\/p>\n

He added, “When a crucial component of the therapeutic plan, such as medications like GLP-1, is discontinued, the disease process tends to resume at a rapid pace.”<\/p>\n

Because the study was observational in design<\/a>, it could only prove an association, not causation, the researchers acknowledged.<\/p>\n

CLICK HERE FOR MORE HEALTH STORIES<\/strong><\/a><\/p>\n

Al-Aly noted, however, that they used “target trial emulation, which applies the logic and rigor of a randomized experiment to real-world data,” and they adjusted for clinical conditions as they changed over time.<\/p>\n

Also, because the study was done with mainly older male veterans<\/a>, the findings may not apply to more general populations.<\/p>\n

CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER<\/strong><\/a><\/p>\n

“The patients in this study were at a higher risk of developing coronary artery disease,” Serwer pointed out. “Many individuals taking GLP-1 medications do so for weight loss, and may not necessarily have significant cardiovascular risk factors, such as diabetes<\/a>, hypertension or hyperlipidemia.”<\/p>\n

Other factors, such as medication adherence and reasons for stopping, could have impacted the results, the researchers noted.<\/p>\n

Based on the findings, the researchers say GLP-1 drugs should be considered as long-term treatments.<\/p>\n

“When people stop GLP-1 drugs, it’s not just weight that comes back<\/a>,” Al-Aly said. “They experience a resurgence in inflammation, blood pressure, cholesterol and insulin resistance.”\u00a0<\/p>\n

Unlike weight regain, the metabolic reversal is “silent and invisible,” he cautioned.<\/p>\n

“It doesn’t announce itself until it surfaces in the ER as a heart attack or a stroke. We think of this as a form of \u2018metabolic whiplash,\u2019 and our data suggest it is detrimental to heart health.”<\/p>\n

Serwer added that while GLP-1s are designed to enhance metabolic health, they should be combined with healthy behaviors to help ensure long-term benefits.<\/p>\n

TEST YOURSELF WITH OUR LATEST LIFESTYLE QUIZ<\/strong><\/a><\/p>\n

“It is crucial to adopt a holistic approach that emphasizes lifestyle modifications<\/a>, diet and exercise,” he said.<\/p>\n

“All medications have their advantages and disadvantages. It is essential to engage in a comprehensive discussion with your medical providers to carefully evaluate the potential benefits and risks.”<\/p>\n<\/div>\n

Source – https:\/\/www.foxnews.com\/health\/stopping-glp-1-drugs-like-ozempic-erodes-heart-health-benefits-quickly-new-study-finds <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

People who stop taking popular weight-loss and diabetes medications may lose out on any heart health benefits the medications provided. 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