{"id":118120,"date":"2026-01-22T14:27:42","date_gmt":"2026-01-22T19:27:42","guid":{"rendered":"https:\/\/cablemanpro.com\/wallstreetpr\/jelly-rolls-wife-says-weight-loss-drug-sent-her-into-worst-suicidal-depression-118120"},"modified":"2026-01-22T14:27:42","modified_gmt":"2026-01-22T19:27:42","slug":"jelly-rolls-wife-says-weight-loss-drug-sent-her-into-worst-suicidal-depression","status":"publish","type":"post","link":"https:\/\/cablemanpro.com\/wallstreetpr\/jelly-rolls-wife-says-weight-loss-drug-sent-her-into-worst-suicidal-depression-118120","title":{"rendered":"Jelly Roll&#8217;s wife says weight-loss drug sent her into \u2018worst suicidal depression\u2019"},"content":{"rendered":"<div>\n<p><i>This story discusses suicide. If you or someone you know is having thoughts of suicide, please contact the Suicide &amp; Crisis Lifeline at 988 or 1-800-273-TALK (8255).<\/i><\/p>\n<p>Bunnie XO, the wife of country singer Jelly Roll, is discussing how a weight-loss medication may have led to her experiencing a <a href=\"https:\/\/www.foxnews.com\/category\/health\/mental-health\/depression\" target=\"_blank\" rel=\"noopener\">&#8220;dark&#8221; depression<\/a>.<\/p>\n<p>During an episode of her podcast &#8220;Dumb Blonde,&#8221; Bunnie, whose real name is Alyssa DeFord, revealed that she had been taking a new drug by Lilly called retatrutide (reta), which is currently in late-stage trials and not approved by the FDA.<\/p>\n<p><a href=\"https:\/\/www.foxnews.com\/health\/what-glp-3s-meet-new-generation-weight-loss-drugs-three-key-ingredients\" target=\"_blank\" rel=\"noopener\"><strong>WHAT ARE GLP-3S? MEET THE NEW GENERATION OF WEIGHT-LOSS DRUGS WITH THREE KEY INGREDIENTS<\/strong><\/a><\/p>\n<p>Bunnie, 45, confirmed that she received her dose from a &#8220;reputable wellness center&#8221; in Nashville, and felt sick within the first week. Within two weeks, she noticed she looked and felt slimmer. In the fourth week, she <a href=\"https:\/\/www.foxnews.com\/category\/health\/healthy-living\/medications\" target=\"_blank\" rel=\"noopener\">increased her dose<\/a> by one unit, which is when she noticed the &#8220;mental numbness.&#8221;<\/p>\n<p>&#8220;I literally got sent into the worst suicidal depression that I&#8217;ve had since 2020,&#8221; she said. &#8220;I&#8217;m talking like it scared me so bad. I didn&#8217;t think I was going to make it through the two weeks. Like I was praying to God.&#8221;<\/p>\n<p>The podcaster shared how she had &#8220;no emotion&#8221; and couldn\u2019t listen to music that would typically &#8220;bring me joy.&#8221;<\/p>\n<p>&#8220;You could see like my eyes were black,&#8221; she said. &#8220;I just drove in silence because I just couldn&#8217;t handle anything. It was either overstimulating or it was to the point where it just <a href=\"https:\/\/www.foxnews.com\/category\/health\/mental-health\" target=\"_blank\" rel=\"noopener\">stole my joy<\/a>. I had no joy, like nothing to live for. It was so dark.&#8221;<\/p>\n<p><a href=\"https:\/\/www.foxnews.com\/health\/obesity-expert-reveals-best-way-decide-glp-1s-right-you\" target=\"_blank\" rel=\"noopener\"><strong><u>OBESITY EXPERT REVEALS THE BEST WAY TO DECIDE IF GLP-1S ARE RIGHT FOR YOU<\/u><\/strong><\/a><\/p>\n<p>After 20 days off the drug, Bunnie reported that her joy is &#8220;finally&#8221; returning, calling the experience a &#8220;battle.&#8221;<\/p>\n<p>&#8220;My story is not what&#8217;s going to happen to you,&#8221; she shared with her listeners. &#8220;There&#8217;s so many people who are taking reta and love it and all that. But something happened with me.&#8221;<\/p>\n<p>Indiana-based drug-maker Lilly confirmed in a statement to Fox News Digital that retatrutide is an &#8220;investigational molecule that is legally available only to participants in Lilly\u2019s clinical trials.&#8221;<\/p>\n<p>&#8220;No one should consider taking anything claiming to be retatrutide outside of a Lilly-sponsored clinical trial,&#8221; the spokesperson wrote. &#8220;This was not a Lilly product, and the company continues to warn the public about the potential dangers of fake medicines.&#8221;<\/p>\n<p>Fox News senior medical analyst Dr. Marc Siegel reacted in an interview with Fox News Digital, warning that retatrutide should not be taken while it has still not received <a href=\"https:\/\/www.foxnews.com\/category\/us\/crime\/drugs\" target=\"_blank\" rel=\"noopener\">FDA approval<\/a> unless it is part of a clinical trial.<\/p>\n<p>&#8220;This drug is new \u2014 known as a triple agonist (GLP-1, GIP and glucagon receptor agonist),&#8221; he said. &#8220;[It] has been linked potentially to depression and suicidal thoughts, as have the GLP-1 drugs, where some studies have shown increased psychiatric risks, so there is a potential link here.&#8221;<\/p>\n<p>The drug has received the nickname &#8220;GLP-3&#8221; because it targets the three hormones, which experts suggest could lead to more substantial weight loss.<\/p>\n<p>Lilly announced results from its phase 3 trial TRIUMPH-4 in December, which tested retatrutide\u2019s effect on weight loss and other <a href=\"https:\/\/www.foxnews.com\/health\" target=\"_blank\" rel=\"noopener\">health conditions<\/a>.<\/p>\n<p>Participants with obesity and <a href=\"https:\/\/www.foxnews.com\/category\/health\/pain-management\/arthritis\" target=\"_blank\" rel=\"noopener\">knee arthritis<\/a> who took a 12-mg dose of retatrutide saw an average weight loss of 71.8 lbs (28.7%) at 68 weeks.<\/p>\n<p>&#8220;We believe retatrutide could become an important option for patients with significant weight loss needs and certain complications, including knee osteoarthritis,&#8221; a Lilly spokesperson said in a statement to Fox News Digital.<\/p>\n<p>Seven additional phase 3 trials for retatrutide are expected to wrap up in 2026. The drug could see FDA approval in 2027, according to GoodRx.<\/p>\n<p><a href=\"https:\/\/www.foxnews.com\/health\/study-reveals-how-rapidly-weight-comes-back-after-quitting-obesity-medications\" target=\"_blank\" rel=\"noopener\"><strong><u>STUDY REVEALS HOW RAPIDLY WEIGHT COMES BACK AFTER QUITTING OBESITY MEDICATIONS<\/u><\/strong><\/a><\/p>\n<p>Despite limited data availability on the drug, the medication could also be applied to treat other conditions like type 2 diabetes, kidney disease, cardiovascular risk reduction and metabolic dysfunction, according to GoodRx and other experts.<\/p>\n<p>Siegel confirmed that retatrutide&#8217;s side effects can be similar to other GLP-1s, including <a href=\"https:\/\/www.foxnews.com\/category\/health\/digestive-health\" target=\"_blank\" rel=\"noopener\">gastrointestinal symptoms<\/a> and other rare reactions like pancreatitis, gallstones and heart arrhythmia.<\/p>\n<p>Philip Rabito, M.D., a specialist in endocrinology, weight loss and wellness in New York City, shared in a previous interview with Fox News Digital that this new class of weight-loss drugs is positioned to &#8220;approach bariatric surgery level outcomes&#8221; \u2014 although it doesn&#8217;t come without risks.<\/p>\n<p>&#8220;The novel glucagon\u2011agonist component introduces less\u2011understood long\u2011term safety considerations, so it is imperative that patients are followed closely by <a href=\"https:\/\/www.foxnews.com\/category\/health\/health-care\" target=\"_blank\" rel=\"noopener\">healthcare professionals<\/a> experienced with this class of medicines, with cautious, stepwise use, despite the impressive efficacy,&#8221; he cautioned.<\/p>\n<p>The potential link between mental health symptoms and weight-loss drugs is most likely due to the impact on the <a href=\"https:\/\/www.foxnews.com\/category\/health\/brain-health\" target=\"_blank\" rel=\"noopener\">brain&#8217;s reward system<\/a>, according to Siegel.<\/p>\n<p>&#8220;Dopamine, serotonin and norepinephrine affect mood and appetite, reduce cravings and can have a positive effect on mood, but also can be negative,&#8221; he said. &#8220;Somewhat unpredictable.&#8221;<\/p>\n<p>Dr. Peter Balazs, a hormone and weight loss specialist in New York and New Jersey, noted that any presentation of significant depressive symptoms, particularly those including &#8220;psychotic features and suicidal ideation,&#8221; requires a full <a href=\"https:\/\/www.foxnews.com\/category\/health\/health-care\" target=\"_blank\" rel=\"noopener\">clinical evaluation<\/a>.<\/p>\n<p><a href=\"https:\/\/www.foxnews.com\/newsletters?cmpid=fnfirstnl\" target=\"_blank\" rel=\"noopener\"><strong>CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER<\/strong><\/a><\/p>\n<p>&#8220;It is essential to understand the patient&#8217;s complete medical and psychiatric history, including other <a href=\"https:\/\/www.foxnews.com\/health\" target=\"_blank\" rel=\"noopener\">medical conditions<\/a>, precise weight change dynamics, concomitant medications and psychosocial stressors,&#8221; he said. &#8220;Major depressive episodes are multifactorial \u2014 attributing them to a single agent without this context is premature.&#8221;\u00a0<\/p>\n<p>Any individual experiencing these symptoms should &#8220;seek immediate professional help,&#8221; Balazs said.<\/p>\n<p>&#8220;We are still learning about the psychiatric effects of these medications, even the ones that have already been approved,&#8221; he added.<\/p>\n<p><a href=\"https:\/\/www.foxnews.com\/health\" target=\"_blank\" rel=\"noopener\"><strong>CLICK HERE FOR MORE HEALTH STORIES<\/strong><\/a><\/p>\n<p>Bunnie&#8217;s age would typically place her in the <a href=\"https:\/\/www.foxnews.com\/category\/health\/endocrine\/menopause\" target=\"_blank\" rel=\"noopener\">perimenopausal stage<\/a>, which can include &#8220;significant fluctuations&#8221; in reproductive hormones like estrogen, Balazs noted.<\/p>\n<p>&#8220;Estrogen has well-documented neuroprotective and mood-stabilizing effects,&#8221; he said. &#8220;Its decline can render the brain more vulnerable to stress and dysregulation, potentially precipitating or exacerbating depressive episodes.&#8221;<\/p>\n<p><a href=\"https:\/\/www.foxnews.com\/category\/health\/nutrition-and-fitness\/obesity\" target=\"_blank\" rel=\"noopener\">Obesity can also cause<\/a> hormone shifts and inflammation that can interfere with normal brain function, sometimes affecting mood and emotional balance, the expert noted.<\/p>\n<p><a href=\"https:\/\/www.foxnews.com\/category\/lifestyle\/quizzes\" target=\"_blank\" rel=\"noopener\"><strong>TEST YOURSELF WITH OUR LATEST LIFESTYLE QUIZ<\/strong><\/a><\/p>\n<p>Balazs stressed that experts should be &#8220;vigilant&#8221; in monitoring symptoms of people taking these medications.\u00a0<\/p>\n<p>&#8220;Until a protocol is established, patients outside clinical trials should not inject these medications,&#8221; he cautioned. &#8220;Dose and dose-related responses can change the whole experience.&#8221;<\/p>\n<\/div>\n<p><a href=\"https:\/\/www.foxnews.com\/health\/jelly-rolls-wife-says-weight-loss-drug-sent-her-worst-suicidal-depression\">Source &#8211; https:\/\/www.foxnews.com\/health\/jelly-rolls-wife-says-weight-loss-drug-sent-her-worst-suicidal-depression <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>This story discusses suicide. If you or someone you know is having thoughts of suicide, please contact the Suicide &amp; Crisis Lifeline at 988 or [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"rop_custom_images_group":[],"rop_custom_messages_group":[],"rop_publish_now":"initial","rop_publish_now_accounts":{"twitter_2902945987_2902945987":""},"rop_publish_now_history":[],"rop_publish_now_status":"pending","footnotes":""},"categories":[16563],"tags":[],"stock_ticker":[],"class_list":["post-118120","post","type-post","status-publish","format-standard","hentry","category-market-news","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Jelly Roll&#039;s wife says weight-loss drug sent her into \u2018worst suicidal depression\u2019 - Wall Street PR<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cablemanpro.com\/wallstreetpr\/jelly-rolls-wife-says-weight-loss-drug-sent-her-into-worst-suicidal-depression-118120\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Jelly Roll&#039;s wife says weight-loss drug sent her into \u2018worst suicidal depression\u2019 - Wall Street PR\" \/>\n<meta property=\"og:description\" content=\"This story discusses suicide. 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