{"id":115134,"date":"2025-12-29T07:00:51","date_gmt":"2025-12-29T12:00:51","guid":{"rendered":"https:\/\/cablemanpro.com\/wallstreetpr\/alzheimers-disease-could-be-reversed-by-restoring-brain-balance-study-suggests-115134"},"modified":"2025-12-29T07:00:51","modified_gmt":"2025-12-29T12:00:51","slug":"alzheimers-disease-could-be-reversed-by-restoring-brain-balance-study-suggests","status":"publish","type":"post","link":"https:\/\/cablemanpro.com\/wallstreetpr\/alzheimers-disease-could-be-reversed-by-restoring-brain-balance-study-suggests-115134","title":{"rendered":"Alzheimer\u2019s disease could be reversed by restoring brain balance, study suggests"},"content":{"rendered":"
\n

Scientists may have pinpointed a way to reverse Alzheimer\u2019s disease<\/a> in an animal study.<\/p>\n

The study, led by University Hospitals Cleveland Medical Center, found that restoring a central cellular energy molecule in mice\u2019s brains reversed the markers of the disease, including brain changes and cognitive decline.<\/p>\n

Researchers analyzed two Alzheimer\u2019s mouse models \u2014 as well as human Alzheimer\u2019s brain tissue \u2014 and found severe levels of NAD+ decline.<\/p>\n

NEW VITAMIN COMPOUND SHOWS PROMISE FOR REVERSING ALZHEIMER’S DAMAGE TO THE BRAIN\u00a0<\/strong><\/a><\/p>\n

NAD+, an enzyme that is essential for energy production, cell maintenance and long-term cell health<\/a>, naturally declines with age, according to senior study author Andrew A. Pieper, M.D., Ph.D., director of the Brain Health Medicines Center at Harrington Discovery Institute at University Hospitals in Cleveland, Ohio.<\/p>\n

“When NAD+ falls below necessary levels, cells cannot effectively perform essential maintenance and survival functions,” he told Fox News Digital.<\/p>\n

Dr. Charles Brenner, chief scientific advisor for Niagen, which specializes in products that boost NAD+ levels, shared that NAD+ plays a significant role in powering organs that require high energy, including the brain.<\/p>\n

“The brain consumes around 20% of your body\u2019s energy and has high demand for NAD+ for cellular energy production and DNA repair<\/a>,” Brenner, who was not involved in the study, told Fox News Digital. “This is because NAD+ plays a key role in the way that neurons adapt to a range of physiological stressors and support processes associated with brain health.”<\/p>\n

Research demonstrates the potential benefits of NAD+ supplementation in brain health conditions such as Alzheimer\u2019s disease, Parkinson\u2019s disease and ataxia telangiectasia, he added.<\/p>\n

In the UH Cleveland study, researchers used a medication<\/a> called P7C3-A20 to restore normal levels of NAD+ in mice models, which was found to block the onset of Alzheimer\u2019s. In brains with advanced Alzheimer\u2019s, it reversed amyloid and tau build-up and fully restored cognitive function, according to the researchers.\u00a0<\/p>\n

ALZHEIMER’S RISK DECLINES SHARPLY WITH ONE DAILY LIFESTYLE CHANGE, RESEARCHERS SAY<\/strong><\/a><\/p>\n

\u200b\u200bTreated mice also showed normalized blood levels of phosphorylated tau 217, an important clinical biomarker used in human Alzheimer\u2019s research.<\/p>\n

“For more than a century, Alzheimer’s has been considered irreversible,” Pieper said. “Our experiments provide a proof of principle that some forms of dementia may not be inevitably permanent.”<\/p>\n

The researchers were “struck” by how robustly the advanced Alzheimer\u2019s was reversed in mice\u2019s brains when NAD+ homeostasis was restored, even without directly targeting amyloid plaques<\/a>.<\/p>\n

“This gives reason for cautious optimism that similar strategies may one day benefit people,” Pieper added.<\/p>\n

CLICK HERE FOR MORE HEALTH STORIES<\/strong><\/a><\/p>\n

This work builds on previous research from the lab demonstrating that restoring NAD+ balance<\/a> helped to speed recovery after severe traumatic brain injury.<\/p>\n

The study \u2014 which was conducted along with Case Western Reserve University and the Louis Stokes Cleveland VA Medical Center \u2014 was published last week in the journal Cell Reports Medicine.<\/p>\n

The main limitation of the study is that it was only conducted in mouse models<\/a> and may not directly translate to the disease in humans, according to the researchers.<\/p>\n

“Alzheimer’s is a complex, multifactorial, uniquely human disease,” Pieper told Fox News Digital. “Efficacy in animal models does not guarantee the same results in human patients.”<\/p>\n

CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER\u00a0<\/strong><\/a><\/p>\n

While drugs have been tested in clinical trials<\/a> with the goal of slowing Alzheimer\u2019s progression, none have been tested for reversal in humans.<\/p>\n

The authors also warned that over-the-counter NAD+-boosting supplements<\/a> can raise cellular NAD+ to excessively high levels that, in some animal models, have been shown to promote cancer.\u00a0<\/p>\n

“P7C3-A20, by contrast, enables cells to restore and preserve appropriate NAD+ balance under stress without driving NAD+ to excessively high levels,” Pieper noted.<\/p>\n

Anyone considering NAD+-modulating supplements should discuss the risks and benefits with their physician, he recommended.<\/p>\n

There are also proven lifestyle measures<\/a> that promote brain resilience, according to the researcher.<\/p>\n

“These include prioritizing sufficient sleep, following a MIND or Mediterranean diet, staying cognitively and physically active, maintaining social connections, addressing hearing loss<\/a>, protecting your head from physical injury, limiting alcohol, and controlling blood pressure and other cardiovascular risk factors like avoiding smoking,” Pieper advised.<\/p>\n

TEST YOURSELF WITH OUR LATEST LIFESTYLE QUIZ\u00a0<\/strong><\/a><\/p>\n

Looking ahead, the team plans to conduct further research into the impact of brain energy balance on cognitive health, and to test whether the strategy works for other age-related neurodegenerative diseases.<\/p>\n<\/div>\n

Source – https:\/\/www.foxnews.com\/health\/alzheimers-disease-could-reversed-restoring-brain-balance-study-suggests <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Scientists may have pinpointed a way to reverse Alzheimer\u2019s disease in an animal study. 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